Characterization of L-amino Acid Oxidase Derived from Crotalus adamanteus Venom: Procoagulant and Anticoagulant Activities
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چکیده
منابع مشابه
Crystalline L-amino acid oxidase of Crotalus adamanteus.
Enzymes that catalyze the oxidation of amino acids have been found in microorganisms, mammals, and lower animals. As yet, few of these have been obtained in a state of high purity, and many studies on these enzymes have therefore been carried out with relatively crude preparations. The detailed mechanism of the flavoprotein-cat.alyzed oxidative dcamination of amino acids remains to be <Jlucidat...
متن کاملMathematical modelling of amino acid resolution catalyzed by L-amino acid oxidases from Crotalus adamanteus and Crotalus atrox
Amino acid resolutionwas studied in this paper. L-Methionine and DL-methioninewere used as substr for the two snake venom L-amino acid oxidases (from Crotalus adamanteus and Crotalus atrox). E though these enzymes have similar background, they exhibit differences as well as similarities. It found that both enzymes are active towards L-methionine as substrate (Vm = 0.78 mmol min 1 g ) have simil...
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Some constituents of snake venom have been found to display a variety of biological activities. The antibacterial property of snake venom, in particular, has gathered increasing scientific interest due to antibiotic resistance. In the present study, king cobra venom was screened against three strains of Staphylococcus aureus [including methicillin-resistant Staphylococcus aureus (MRSA)], three ...
متن کاملInactivation of snake venom L-amino acid oxidase by freezing.
The L-amino acid oxidase of Crotalus adamanteus is inactivated by storage in the frozen state at temperatures between -5” and -60°, with maximal inactivation being observed at approximately -20”. The rate of inactivation is dependent on the pH of storage and on the ionic composition of the medium. The inactivation is accompanied by changes in the visible absorption spectrum and by a decrease in...
متن کاملan Experimental Glomerular Lesion Caused by Venom (crotalus Adamanteus)
The venom of Crotalus adamanteus when administered intravenously to rabbits in properly graded doses causes lesions of the glomerulus of tile kidney which may be either hemorrhagic or exudative in character. Both types of lesion are usually associated but either one or the other may predominate. The hemorrhagic lesion, which may be confined to the glomerular tuft, or, by rupture of the latter, ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20194853